Caught in the act (IMAGE)

School of Science, The University of Tokyo

Caught in the act

Caption

The bacterial enzyme SacC builds the five-ring core shared by safracin B and the anticancer drug ecteinascidin 743 (trabectedin), forming two new carbon-to-carbon bonds through a seven-step catalytic cascade. Above, the enzyme is seen by cryo-electron microscopy, with its working parts in different colors.

Credit

Haraguchi et al, 2026

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Credit must be given to the creator.

License

CC BY

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