PRIMA-1 Effects (IMAGE)

Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem (INBEB)

PRIMA-1 Effects — Caption

PRIMA-1/MQ effects on amyloid-state p53. 1) PRIMA-1 mobilizes the aggregated p53 pool and stabilizes mutant p53, resulting in the recovery of wild-type p53 functions and in the reduction of the cellular amyloid content. 2) PRIMA-1/MQ blocks the seeding of wild-type p53C aggregation by mutant p53 present in cell lysates, which might be part of the general effect of PRIMA-1/MQ on p53 seen in mutant p53 cancer cells.

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Luciana P. Rangel and Giulia D. S. Ferretti

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