Working Model (IMAGE)
Caption
Origin selection: H2A.Z nucleosomes bind Suv420H1 directly to establish H4K20me2 on chromatin, which then recruits ORC1 to bind to replication origins; Origin firing: H2A.Z-Suv420H1-H4K20me2-ORC1 axis selectively license and activate early replication origins.
Credit
Image by Dr. LI Guohong's lab
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