The Compound GA-Hecate (IMAGE)

Fundação de Amparo à Pesquisa do Estado de São Paulo

The Compound GA-Hecate

Caption

The compound called GA-Hecate also acts on bacteria, fungi and cancer cells and will be tested against Zika and yellow fever viruses (action mechanism proposed for GA-Hecate. Upper half of figure (low concentrations of material): (1) HCV; (2) interaction between GA-Hecate and viral envelope, destruction of virus and release of genetic material (+ssRNA); (3) interaction between GA-Hecate and host cell membrane, with permeabilization of peptide; (4) lipid droplet; (5) interaction between compound and lipid droplets, breaking down the latter and releasing replication complex proteins. Lower half (high concentrations of material): (1) interaction between compound and host cell plasma membrane; disruption resulting in cell death; (2) interaction with viral envelope and destruction of virus

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Paulo Ricardo da Silva Sanches

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