Bispecific Antibodies Neutralize SARS-CoV-2 Variants (IMAGE)

American Association for the Advancement of Science (AAAS)

Bispecific Antibodies Neutralize SARS-CoV-2 Variants

Caption

Monoclonal antibodies targeting the SARS-CoV-2 spike protein were isolated from donors who had recovered from COVID-19. Pairs of potent monoclonal antibodies that bound distinct regions of the spike protein were combined into bispecific antibodies. These bispecific antibodies prevented SARS-CoV-2 variants of concern from infecting cells in vitro and prevented disease in hamsters infected with SARS-CoV-2.

Credit

Ethan Tyler, NIH Medical Arts Branch

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