Protein lactylation induced by neural excitation (IMAGE)

Fujita Health University

Protein lactylation induced by neural excitation

Caption

This paper shows that protein lactylation in brain cells is regulated by neural activation and social defeat stress, paralleled with changes in lactate levels. The stress specifically enhances lysine lactylation of histone H1 proteins in neurons in the prefrontal cortex (PFC).

Credit

Hagihara H, et al. Cell Rep 2021

Usage Restrictions

Credit attributed

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.