Molecular balance requirement for learning and memory. (IMAGE)
Caption
(A) In a brain region known as the striatum, learning and memory are inhibited by D2R, and facilitated by RGS. (B) Normal learning and memory are realized only if the concentrations of D2R and RGS are balanced in a certain level (blue shaded area), and the concentration of RGS is over a certain level (red shaded area). The concentrations of D2R and RGS are balanced in healthy development (green and gray points), but disrupted in schizophrenia and DYT1 dystonia (blue and red points, respectively).
Credit
Hidetoshi Urakubo
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