Figure 1 (IMAGE) Compuscript Ltd Caption Secoemestrin C sulfates endoplasmic reticulum (ER) cysteines to disrupt disulfide-bonds formation in ER proteins, causing ER stress. Meanwhile, ER stress is cooperatively enhanced by ERAD-induced YAP degradation via YAP–Axin–GSK–βTrCP complex formation. Credit APSB Usage Restrictions No restrictions. License Public Domain Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.