COVID-19患者中CLYBL的高表达可能导致衣康酸下调 (IMAGE)

Science China Press

COVID-19患者中CLYBL的高表达可能导致衣康酸下调

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CLYBL的显著高表达会导致上游代谢产物衣康酸的消耗。衣康酸可抑制三羧酸循环中的琥珀酸脱氢酶SDH，通过KEAP1的烷基化激活NFE2L2，还可以抑制caspase-1介导的IL-1β、IL-18的裂解，阻断NLRP3炎症小体的激活从而避免过度的炎症反应。

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©《中国科学》杂志社

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