Summary of DHA-mediated immunoregulation and potential mechanism (IMAGE)
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DHA promoted the reversible expansion of effective regulatory T cells (green), interferon-γ+ cytotoxic CD8+ T cells (red), and MHCIIlow follicular (Fo) B cells(blue) in mouse spleen (left panel) via induction of superoxide dismutase 3 (SOD3) expression, increased phosphorylation of c-Jun N-terminal kinases and its downstream activator protein 1 transcription factors (right panel).
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