Molecular Profiling of COVID-19 Autopsies Uncovers Novel Disease Mechanisms (IMAGE)

Elsevier

Molecular Profiling of COVID-19 Autopsies Uncovers Novel Disease Mechanisms

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. (A) Four major regulatory pathways seen in infected tissues: structure and degradation, blood vessel development, cytokine production, and cell activation. (B) Olfactory bulb and prefrontal cortex were evaluated using single-nuclei RNAseq (Illustration by Jill Gregory, used with permission from © Mount Sinai Health System). (C) Diverse repertoire of potential SARS-CoV-2 entry receptors across microanatomical cellular niches in the brain. (D) Formalin-fixed, paraffin-embedded lung sections from Patient 1 and Patient 2 with representative regions of interest (ROIs) that were assessed using digital spatial profiling.

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The American Journal of Pathology

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