Target Therapy for Triple Negative Breast Cancer (IMAGE)

Advanced Science Research Center, GC/CUNY

Target Therapy for Triple Negative Breast Cancer

Caption

The illustrations show how coordination of the proteins mtp53 R273H, PARP, and MCM2-7 on replicating DNA likely play a role in tumor development for some breast cancers. In figure A, MCM2-7 (shown in purple), mtp53 R273H (shown in green), and PARP (shown in red) interact with replicating DNA. When cell damage occurs, they help facilitate aberrant repair, allowing cells to survive and promoting tumor development. In figure B, high PARP and mtp53-expressing cells are treated with talazoparib (shown in yellow) in combination with temozolomide, which allows PARP to be trapped on replicating chromatin. This increases disrepair of DNA damage, promoting cell death and preventing tumor development.

Credit

Gu Xiao

Usage Restrictions

Use only in conduction with this study

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.