The suggested disease model of multifocal osteomyelitis in MSMD patients (IMAGE)

Hiroshima University

The suggested disease model of multifocal osteomyelitis in MSMD patients

Caption

Researchers at Hiroshima University have discovered the mechanism underlying multifocal osteomyelitis in MSMD patients with poor response to IFN-γ. IFN-γ plays an inhibitory role in osteoclast formation. Impaired response to IFN-γ in MSMD patients leads to excessive osteoclast proliferation and, by inference, increases bone resorption in infected foci, which may underlie multifocal osteomyelitis.

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Satoshi Okada, et al., Hiroshima University

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