A framework for precision nutrigeroscience (IMAGE)
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A framework for precision nutrigeroscience based on optimizing diet/pharmacology based interventions to optimize health and longevity to accommodate factors that lead to individual variation. We propose the concept of precision nutrigeroscience, the study of which will aim to utilize nutrient interventions and compounds that influence nutrient signaling pathways to optimize lifespan, healthspan and tissue-specific decline. However, these interventions need to be optimized based on factors such as sex, genetics, epigenetics, and age to optimize the desired outcomes. Furthermore, the use of biomarkers like circulating factors in the blood from transcriptomic, proteomic or metabolomic changes associated with health outcomes could be used to appropriately change the nutrient and pharmacologic interventions to optimize health outcomes. Together the combination of these approaches could help achieve the goals of precision nutrigeroscience.
Credit
Kenneth Wilson, PhD
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