Hypervirulent C. difficile (IMAGE)

University of California - Irvine

Hypervirulent C. difficile

Caption

The VPI10463 and M68 represent the classic and the hypervirulent C. difficile, respectively. GTD-VPI preferentially modifies Rho family GTPases (Cdc42, for example) by glucosylation, while GTD-M68 more effectively modifies R-Ras. Due to their different selectivity toward Rho or Ras family GTPases, these two different TcdB variants cause two distinct types of cytopathic effects.

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UCI School of Medicine

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