Miscarriage rescue in mice (IMAGE)

RIKEN

Miscarriage rescue in mice

Caption

Cartoon rendering of the first experiment. (Left) The normal situation in wildtype mice. (Middle) When egg cells do not contain H3K27 trimethylation, maternal Xist is active and lethal for males. (Right) Additional knockout (KO) of maternal Xist prevents male-skewed prenatal death (miscarriages). Further KO of other genes that failed to imprint rescued the enlarged maternal placenta (not depicted).

Credit

RIKEN

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credit RIKEN

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