METHIONINE CYCLE REWIRING BY miR-873-5p NEGATIVE MODULATION PROTECTS AGAINST ACETAMINOPHEN OVERDOSE DETRIMENTAL EFFECTS (IMAGE)

CIC bioGUNE

METHIONINE CYCLE REWIRING BY miR-873-5p NEGATIVE MODULATION PROTECTS AGAINST ACETAMINOPHEN OVERDOSE DETRIMENTAL EFFECTS

Caption

APAP-induced DILI leads to dysregulation of ammonia levels. The negative modulation of miR-873-5p restores methionine cycle activity, attenuates ammonia accumulation, and increases polyamine synthesis activity. All in all, these facts improve the regenerative capacity and thus restore the physiological activity of the liver.

Credit

Ruben Rodiguez, CIC bioGUNE

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