UHRF1 controls DNA methylation of synovial fibroblasts in RA patients. (IMAGE)

Ehime University

UHRF1 controls DNA methylation of synovial fibroblasts in RA patients.

Caption

The UHRF1 expression level is elevated in SF, particularly under RA pathogenesis, but not OA. Sufficient levels of UHRF1 can reduce mRNA expression levels of genes that encode multiple RA-exacerbating factors such as RA-related, cytokine-related and anti-apoptosis-related genes by altering DNA methylation. In contrast, insufficient UHRF1 expression levels are associated with the progression of RA pathogenesis.

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Ehime University

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