A Diagram Demonstrating how IGFBP7 prevents DPSC senescence and promotes tissue regeneration (IMAGE)
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A-F, The IGFBP7 knockdown promote DPSCs senescence and attenuated tissue regeneration in vivo. G-H, The IGFBP7 knockdown inhibits the metabolism of DPSCs. I-J, The IGFBP7 overexpression promotes the metabolism of DPSCs. K-N, The IGFBP7 inhibits transcription of p21 by decreasing H3K36ac. O, Schematic diagram of the mechanism.
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