(IMAGE)

Hong Kong University of Science and Technology

Caption

The diagram shows how increased sST2 levels in AD impair microglial clearance of amyloid pathology: increased levels of sST2 protein (1) in the blood enter the brain; this decoy receptor blocks the normal signaling stimulated by IL-33 in microglia (2). The inhibition of IL-33 signaling leads to reduced clearance of Aβ by microglia (3), resulting in an increase in Aβ plaque load (4).

Credit

HKUST

Usage Restrictions

N.A.

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Original content

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