Cellular housekeeping process implicated in fatal neurological disorder (IMAGE)
Caption
A study from Washington University School of Medicine in St. Louis shows that as patients age, Huntington's disease impairs autophagy, which eliminates waste from cells. Shown at left are neurons transformed from skin cells of a young patient with pre-symptomatic Huntington's disease. On the right are neurons transformed from skin cells of an older patient with symptomatic Huntington's; these cells are sparse because the aging process impairs autophagy, leading to cell death.
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YOUNGMI OH, SEONGWON LEE
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