Fig. 1. Lasso-grafting to design molecules that mimic growth factors with longer retention and brain penetration. (IMAGE)

Kanazawa University

Fig. 1. Lasso-grafting to design molecules that mimic growth factors with longer retention and brain penetration.

Caption

© 2022 Sakai, et al. (a) A pharmacophore sequence of Met receptor-binding macrocyclic peptide (aMD4; shown in red) was inserted into the loops (coloured balls) of human IgG1 Fc protein. (b) Lasso-grafting Fc yields Met agonists with extended half-life in the body. (c) Lasso-grafting Fc of an anti-TfR antibody yields Met agonists with blood-brain-barrier (BBB) penetrance.

Credit

Kanazawa University

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