Nose-to-brain drug delivery via the trigeminal nerve innervating the respiratory epithelium (IMAGE)

Tokyo University of Science

Nose-to-brain drug delivery via the trigeminal nerve innervating the respiratory epithelium

Caption

Intranasal administration of PAS-CPP-GLP-2 results in its delivery to the brain via trigeminal axons of the trigeminal nerves. Therefore, it is thought to constitute a nerve-associated transcellular pathway for drug delivery.

Credit

Prof. Chikamasa Yamashita from Tokyo University of Science

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