Genome refolding drives epigenetic adaptation (IMAGE)

University of Pennsylvania School of Medicine

Genome refolding drives epigenetic adaptation

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If you stretched the DNA fiber packed inside of a single cell, it would reach six feet long from end to end — that’s like fitting a ball of yarn twice the size of Manhattan into a tennis ball. To function properly, the strand must be folded just right. Penn researchers have discovered that genome refolding can reposition transcription factors and lead to cancer drug resistance.

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R. Babak Faryabi, PhD, Penn Medicine

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Credit: R. Babak Faryabi, PhD, Penn Medicine

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