(IMAGE)

Université de Genève

Caption

Possible mechanism of action of a drug targeting the SARS-CoV-2 Nsp1. In infected cells, Nsp1 blocks the ribosome’s mRNA channel by acting as a «cork» that prevents the expression of the host’s mRNA. The binding of a ligand to the proposed cryptic pocket highlighted in purple could prevent the Nsp1-mediated blockage and, ultimately, recover the ribosome’s ability to initiate the mRNA translation.

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