Overview of the discoveries and their potential clinical relevance (IMAGE)
Caption
Culturing primary human retinal endothelial cells under hyperglycemic conditions initially compromised their mitochondria. The cells respond by adapting, which included clearance of the dysfunctional mitochondria via mitophagy. Such adaptation is a plausible contributor to the underlying mechanism responsible for the long delay between the onset of diabetes and manifestation of diabetic retinopathy. Furthermore, loss of adaptation may be a prerequisite for development of retinopathy in patients with diabetes.
Credit
The American Journal of Pathology
Usage Restrictions
Please include attribution.
License
Original content