A new model of graft-versus-host-disease (GVHD) (IMAGE)

University of Pittsburgh

A new model of graft-versus-host-disease (GVHD)

Caption

A new model of graft-versus-host-disease (GVHD): Early post transplant (left side), GVHD is initiated by progenitor T cells that seed affected tissues from the spleen and lymph nodes via the blood. In the later phases of GVHD (right side), the disease is maintained locally in the tissues by these long-lived progenitor cells, which differentiate into disease-causing cells.

Credit

Sacirbegovic et al., Immunity, 2023, doi:10.1016/j.immuni.2023.01.003

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