Close-ups of cell nuclei (IMAGE)
Caption
Close-ups of cell nuclei in a human cell culture: HMGB1 protein (green) is usually found throughout the nucleus (dotted line). Mutant HMGB1, shown on the right, preferentially localizes at the nucleolus (marked in magenta) and forms a solidified layer over it, which causes disease.
Credit
MPIMG/ Henri Niskanen
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License
Original content