Figure. Schematic diagram of induction mechanism of acute and chronic liver damage in severe fatty liver (IMAGE)

Kanazawa University

Figure. Schematic diagram of induction mechanism of acute and chronic liver damage in severe fatty liver

Caption

Although mild to moderate fatty liver tends to repair after liver damage, in severe fatty liver, inflammation occurs during the regenerating process after damage and further liver damage is induced. Changes in cell death mode after liver damage play an important role in the pathogenesis. More specifically, the mode of hepatocellular death changes from non-inflammatory apoptosis to inflammatory necroptosis when fatty liver becomes severe. In addition, this change in cell death mode is dependent on the activation of eIF2α signalling/ATF3 associated with aggravation of hepatic steatosis and the accompanying increase in RIPK3 levels.

Credit

Kanazawa University

Usage Restrictions

The image may only be used with appropriate caption and credit.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.