Figure (IMAGE)

Osaka University

Figure

Caption

The proposed model for the recruitment of circulating lymphocytes into milky spots. Aldh1a2+ fibroblastic reticular cell (FRC)-derived retinoic acid induces CXCL12 expression in the endothelium, which regulates the constitutive recruitment of circulating lymphocytes to the milky spots. Additionally, conventional FRCs are also the second source of CXCL12.

Credit

2023, Yasutaka Okabe, Aldh1a2+ fibroblastic reticular cells regulate lymphocyte recruitment in omental milky spots, Journal of Experimental Medicine

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License

CC BY

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