Mea6 deficiency in oligodendrocytes affects white matter formation in the brain (IMAGE)

Higher Education Press

Mea6 deficiency in oligodendrocytes affects white matter formation in the brain

Caption

Model for the function of Mea6 in oligodendrocyte. Mea6 is involved in the transport of different lipids from the ER to the Golgi apparatus, and plays an essential role in the formation and/or maintenance of white matter. cKO of Mea6 affects the composition of major myelin lipid, especially different VLCFAs, leading to the hypomyelination of axons. .

Credit

Tiantian Ma, Wei Mao, Shaohua Zhang, Yaqing Wang, Tao Wang, Jinghua Liu, Lei Shi, Rong Xue, Guanghou Shui, Zhiheng Xu

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