Crystal structure of human CENP-E motor domain – AMPPNP complex (IMAGE)

Tokyo University of Science

Crystal structure of human CENP-E motor domain – AMPPNP complex

Caption

Researchers from Tokyo University of Science unraveled the structure of a complex formed by centromere-associated protein E (CENP-E) motor domain and adenylyl-imidodiphosphate (AMPPNP), a non-hydrolyzable ATP analogue. Understanding this crystal structure could help in the development of promising anticancer drugs with fewer side-effects.

Credit

Hideshi Yokoyama from Tokyo University of Science, Japan. Image link: https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14602

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