Autophagy mediates a direct synergistic interaction during co-transmission of two distinct arboviruses by insect vectors (IMAGE)
Caption
Model depicting Pns11-mediated viral synergism in co-infected vectors. The non-enveloped virions of RSMV assembled at the viroplasm periphery bud into the ER to assemble enveloped virions. RSMV-induced complete autophagy serves as an anti-viral defense mechanism. RGDV Pns11 induces the formation of initial autophagosomes via the recruitment of ATG5-ATG12 conjugation and blocks autophagosome degradation by mediating the reduced expression of N-glycosylated Lamp1 on lysosomal membranes. In co-infected vectors, non-enveloped virions of RSMV bind to Pns11 and then bud into Pns11-induced autophagosomes to assemble enveloped virions via the interaction of N-Pns11-ATG5, finally regulating autophagy from the anti-viral status to pro-viral status during RSMV infection.
Credit
©Science China Press
Usage Restrictions
Use with credit.
License
Original content