Binding mechanism of CELSR cadherin. (IMAGE)

National Institutes of Natural Sciences

Binding mechanism of CELSR cadherin.

Caption

(A) Single-molecule fluorescence microscopy images of CELSR cadherins from adjacent cells. Two differently tagged CELSR cadherins (CELSR2-mGFP and CELSR2-Halo; indicated with arrows) colocalize between cells. (B) High-speed atomic force microscopy (HS-AFM) images of a complex of two interacting CELSR cadherins. A twisted conformation in the strand-like portions of the cadherin ectodomains is visualized using localization analysis of the HS-AFM images. Blue and orange colored arrowheads indicate the tip of each CELSR cadherin.

Credit

Shigetaka Nishiguchi of Scientists at the Exploratory Research Center on Life and Living Systems (ExCELLS)

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CC BY-ND

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