How Transplanted Organoids in Mice Match Human Fetal Development Milestones (IMAGE)

Cincinnati Children's Hospital Medical Center

How Transplanted Organoids in Mice Match Human Fetal Development Milestones

Caption

Top row shows microscopic slides of fetal human intestine over time. Bottom row shows organoid development after transplantation in mice. Arrowhead indicates villus formation, * indicates formation of a new layer of muscle, arrow indicates crypt development. Circular muscle forms at GW8 and tHIO 2wk, longitudinal muscle forms at GW11 and tHIO 4wk, and muscularis mucosae forms at GW 13 and tHIO 6wk.

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Cincinnati Children's

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