Neglected 80-year-old antibiotic is effective against multi-drug resistant bacteria (IMAGE)

PLOS

Neglected 80-year-old antibiotic is effective against multi-drug resistant bacteria

Caption

Streptothricin-F (yellow spheres) bound to the 16S rRNA (green) of the bacterial ribosome impinges on the decoding site where tRNA (purple) binds to the codon of the mRNA (blue). This interaction leads to translation infidelity (scrambled protein sequences), and the resulting death of the bacterial cell. The image was created by overlay of PDB 7UVX containing streptothricin-F (this manuscript) with PDB 7K00 containing mRNA and A-site tRNA (ref DOI: 10.7554/eLife.60482).

Credit

James Kirby (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/); Zoe L Watson et al., 2023, eLife, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

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CC BY

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