Schematic illustration of synthesis of Nanonitrator and salivary gland radiation injury model used to investigate its protective effects. (IMAGE)

Science China Press

Schematic illustration of synthesis of Nanonitrator and salivary gland radiation injury model used to investigate its protective effects.

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A swarm learning-based drug combination prediction system identifying vitamin C as the optimal drug to be combined with sodium nitrate. This combination improved the bioavailability of sodium nitrate and exerted synergistic effects. Subsequently, the team used microencapsulation technology to prepare a nanoparticle named Nanonitrator, with sodium nitrate and vitamin C as its primary components. Nanonitrator prevented tissue damage in a model of radiation-induced salivary gland injury, verifying their improved efficacy over that of sodium nitrate alone.

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