Graphical overview of COVID-19 severity mechanism via alveolar macrophage (IMAGE)

Tokyo Medical and Dental University

Graphical overview of COVID-19 severity mechanism via alveolar macrophage

Caption

Individuals with the T allele at rs13050728 in the IFNAR2/IL10RB locus, which is strongly associated with COVID-19 severity, have high expression of the “hybrid” receptor CiDRE. In addition, in human alveolar macrophages with the T/T genotype, CiDRE enhances IL-10 signaling and attenuates type I IFN signaling as a decoy receptor, promoting severe COVID-19.

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Department of Immunology, TMDU

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