Chemical structures of drugs with cyclopropanes (IMAGE)
Caption
A new method offers a simple, safe, and practical way to create cyclopropanes—a key feature that increases the potency of many drugs and drug-candidates—within molecules. Cyclopropanes are rings of three connected carbon atoms that occur in many drugs currently approved by the FDA, including those used to treat COVID-19, asthma, hepatitis C, and HIV/AIDs. On a chemical diagram, they appear as a triangle (noted here in red), with a carbon atom at each point. One of the carbon atoms is attached to the rest of the drug molecule and the other two are each attached to two hydrogen atoms.
Credit
Giri Lab/Penn State
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