Light-activatable liquid metal nanostimulant in cancer therapy (IMAGE)

Japan Advanced Institute of Science and Technology

Light-activatable liquid metal nanostimulant in cancer therapy

Caption

A versatile liquid metal (LM) gallium-indium alloy has been used to develop a novel LM nanoparticle that harbors an immunomodulant and an immune checkpoint inhibitor, Anti-PD-L1. Upon irradiation by near infra-red light, Anti-PD-L1 specifically binds to the cancer cell, while immunostimulants activate T and dendritic cells. This synergistic activation coupled with the photothermal effect effectively eliminates the cancer cell almost immediately.

Credit

Eijiro Miyako from JAIST.

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