Figure (IMAGE)
Caption
(A) On the neuronal cell membrane, Aβ molecules adopt a "U"-shaped conformation, allining alternately on the membrane surface to form two layers: the β1 layer, distal from the membrane, and the β2 layer, closer to the membrane. This assembly of Aβ acts as a "catalytic platform," accelerating the fibrillation of surrounding Aβ molecules. (B) In previously reported Aβ amyloid fibrils, Aβ molecules align in the same direction.
Credit
Maho Yagi-Utsumi
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