Recent technological breakthroughs greatly advanced our understanding of liver macrophage spatiotemporal diversity. (IMAGE)

First Hospital of Jilin University

Recent technological breakthroughs greatly advanced our understanding of liver macrophage spatiotemporal diversity.

Caption

For instance, single-cell suspensions subjected to single-cell transcriptome analysis revealed the simultaneous presence of multiple immune cell phenotypes. Multiplex immunohistochemistry and imaging mass cytometry showed complex and spatially restricted accumulation of defined monocytic populations. In vivo time-lapse microscopy unravelled the timing of the immune response and dynamic macrophage functionality. Organ clearing and three-dimensional imaging further deepened in situ macrophage biology understanding.

Credit

By Adrien Guillot & Frank Tacke

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CC BY-NC

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