Axonal Initial Segment (IMAGE) Netherlands Institute for Neuroscience - KNAW Caption When there is low activity in the network, the number of sodium channels in the plasma membrane increases to amplify the output. With high activity in the network, the sodium channels are internalised into the cell through ‘endocytosis’. Credit Eline Feenstra - Netherlands Institute for Neuroscience Usage Restrictions Image may be used to illustrate research described in the accompanying release. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.