Latest News Releases 5 August
“While the dip in the employment-to-population ratio for people with disabilities is concerning,” said nTIDE co-author John O’Neill, PhD, director of the Center for Employment and Disability Research at Kessler Foundation, “it still remains above pre-COVID levels and the historic high of 2008, a trend that we’ve seen for 11 months. These data suggest that sampling error may be a factor for this population.”
- Kessler Foundation, National Institute on Disability and Rehabilitation Research
A recent randomized clinical trial validated the usefulness of a strategy for increasing shared decision-making about colorectal cancer screening in older patients.
- Journal of General Internal Medicine
- Patient-Centered Outcomes Research Institute
Researchers from the National Institutes of Health have developed a three-dimensional structure that allows them to see how and where disease mutations on the twinkle protein can lead to mitochondrial diseases. The protein is involved in helping cells use energy our bodies convert from food. Prior to the development of this 3D structure, researchers only had models and were unable to determine how these mutations contribute to disease. Mitochondrial diseases are a group of inherited conditions that affect 1 in 5,000 people and have very few treatments.
- Proceedings of the National Academy of Sciences
- NIH/National Institute of Environmental Health Sciences
PCR tests, also called molecular tests or nucleic acid tests, are considered the gold standard in detecting the presence of SARS-CoV-2, the virus that gives rise to COVID-19. However, they can take a few days to process, resulting in unnecessary quarantine for negative individuals or delays for those who require proof of negative testing for travel or other commitments. Rapid antigen-detecting tests, on the other hand, are convenient, but less reliable than PCR tests.
- ACS Sensors
A new study, which appears in the current issue of the journal Nature Ecology & Evolution, challenges a popular scenario put forward to explain the arrival of the first eukaryotic organisms.
- Nature Ecology & Evolution
Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia—immune cells that reside in the brain—that could provide valuable insights into how they contribute to the development and progression of Alzheimer’s disease (AD). The team’s findings were published in Nature Genetics.
- Nature Genetics
NASA awarded a small business grant to the University of Cincinnati and a Pennsylvania company to develop better autonomous navigation for drones.
Cardiovascular diseases remain a leading cause of death around the world. A primary contributor to these afflictions is high blood pressure, or hypertension. While treatments exist for the condition, which affects tens of millions of Americans, these remedies are not without side effects, and some variants of the disorder are treatment-resistant. The need for more effective therapies to address hypertension-related disease is therefore acute. To accomplish this however, biologists need more detailed maps of the mechanisms underlying cardiovascular regulation. One such regulator is a protein receptor that sits atop cardiovascular cells, acting as a conduit for messages that are transmitted when specific hormone molecules bind with them.
- Scientific Reports
Researchers at Michigan State University have shown that locusts can not only “smell” the difference between cancer cells and healthy cells, but they can also distinguish between different cancer cell lines.
Potato late blight, caused by the destructive fungus Phytophthora infestans, is a severe threat to potato production and global food security. Plant membrane-associated pattern recognition receptors (PRRs) play pivotal roles in regulating immune responses by perceiving pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs) and activating or inhibiting downstream signal transduction to ward off microbes. Plant PRRs include receptor-like kinases (RLKs) and receptor-like proteins (RLPs). RLKs consist of an extracellular domain, a transmembrane domain, and an intracellular kinase domain, whereas RLPs lack the latter. PRRs typically contain extracellular domains such as leucine-rich repeats (LRRs), lectin-like motifs, lysin motifs (LysMs), or epidermal growth factor (EGF)-like domains, based on the characteristics of the ligands they recognize. Lectin receptor-like kinases (LecRLKs) are a large family of RLKs, but the functions of most LecRLKs are poorly understood.
- Horticulture Research
A research team led by Srikanth Singamaneni at Washington University in St. Louis has developed an assay that is versatile, low-cost and adaptable to any laboratory setting and has the potential to provide a more comprehensive look at proteins secreted by cells than the widely used existing assays. This is possible because it uses a plasmonic-fluor, a plasmon-enhanced nanolabel developed in Singamaneni’s lab that is 16,000 times brighter than conventional fluorescence labels and has a signal-to-noise ratio of nearly 30 times higher.
- Cell Reports Methods
- NIH/National Institutes of Health, NIH/National Institutes of Health, NIH/National Institutes of Health, NIH/National Institutes of Health, NIH/National Institutes of Health