IVI, LG Electronics, Korean donors, AHRI and EPHI join hands to vaccinate 100,000 people at risk of cholera in Ethiopia
Business Announcement
The International Vaccine Institute (IVI), in collaboration with LG Electronics, the Ethiopian government led by Armauer Hansen Research Institute (AHRI), and the Ethiopian Public Health Institute (EPHI), will vaccinate 40,000 people against cholera in May to support prevention of the disease in Ethiopia. In a separate but coordinated project funded by other Korean donors, IVI and Ethiopian partners will immunize an additional 60,000 people against the diarrheal disease in Ethiopia.
A significant percentage of very low birth weight (VLBW) premature infants has increased risk of developing brain injury, evolving into cerebral palsy or mental retardation. This work examined the relationship of blood Adenosine concentration to brain lesions diagnosed by MRI in a cohort of fifty-six very low birth weight (VLBW) premature infants. White matter punctate lesions, observed at MRI, are essentially responsible for the neurological complications that challenge the cognitive and physical functioning of about 20% of VLBW babies. High adenosine levels at day 15 post birth were significantly higher in those infants who developed brain white matter lesions, suggests a study led by researchers at IRCCS Istituto Giannina Gaslini Children's Hospital, Genoa, Italy. Also, a moderate negative correlation was found between adenosine level at 15 days post birth and Griffiths Mental Development Scales (GMDS) score, used to assess neurodevelopmental outcome at 12 ± 2 months corrected age. These findings are consistent with previous evidence showing and inverse relationship among blood levels of adenosine and birth weight in premature infants, found during newborn screening program for congenital diseases. This is an important topic to explore further, as adenosine appears an excellent candidate as a biomarker of white matter lesion risk in the premature. As a next step, the Authors will extend the observation to a lager cohort and extend the follow-up study of cognitive performance, by testing the babies at a later age.
Join the experts this October during 13th World Congress of the World Mitochondria Society on Targeting Mitochondria. Many hot topics will be addressed. such as the Mitochondrial Transplantation and Transfer, Extracellular Vesicles & Mitochondria, Translational Therapies, and many more.
Vaccines based on inactivated SARS-CoV-2 virus are commonly used in developing countries due to their low cost. New research from Karolinska Institutet in Sweden shows that a booster shot of mRNA vaccine to individuals who have received two doses of inactivated vaccine offers the same level of protection against COVID-19 as three doses of mRNA vaccine. The findings are published in the journal Nature Communications.
How dangerous are chemicals that we use and come into contact with every day? The "PARC" initiative of the European Union (EU), launched in Paris on 11 May 2022, is breaking new ground in the assessment of chemical substances. "PARC" stands for "European Partnership for the Assessment of Risks from Chemicals". The aim is to improve knowledge about chemical substances in order to better protect human health and the environment. The programme has a total funding volume of €400 million for the next seven years. For Germany, the Federal Institute for Risk Assessment (BfR) and the German Environment Agency (UBA) take on leading roles as work package leads.
The University of Strathclyde and the National University of Singapore (NUS) have signed a memorandum of understanding (MoU) on satellite quantum communications, to pave the way for increased joint experiments between the institutions.
In midlife, the risk of cardiometabolic diseases increases in women more rapidly than in men. A study performed at the Faculty of Sport and Health Sciences of the University of Jyväskylä shows that changes in blood metabolite profile accompany the shift in sex hormone levels during menopause. This finding may help to explain the elevation in cardiometabolic disease risk.
The image is a long-anticipated look at the massive object that sits at the very centre of our galaxy. Scientists had previously seen stars orbiting around something invisible, compact, and very massive at the centre of the Milky Way. This strongly suggested that this object — known as Sagittarius A* (Sgr A*, pronounced "sadge-ay-star") — is a black hole, and today’s image provides the first direct visual evidence of it.
Organisms adjust their cell walls according to environmental conditions such as temperature. Some adaptations involve changes in lipids which may still be preserved long after the rest of the organisms has been degraded. Researchers at the University of Göttingen studied a specific group of lipids called long chain diols which are found in sea sediments all over the world, and which can be preserved for millions of years. The researchers discovered that these lipids are produced by an, until now, unknown group of marine eustigmatophyte algae which evolved before the currently known species originated. This finding changes our understanding of the composition and evolution of these algae, as previously they were considered to consist of a relatively small group of mainly soil and freshwater species. In addition, the researchers show that a ratio of these distinctive lipids, known as the Long chain Diol Index, can be used to reconstruct summer sea surface temperatures from the past. The research was published in the Proceedings of the National Academy of Sciences (PNAS).
Human cell division involves hundreds of proteins at its core. Knowing the 3D structure of these proteins is pivotal to understand how our genetic material is duplicated and passed through generations. The groups of Andrea Musacchio and Stefan Raunser at the Max Planck Institute of Molecular Physiology in Dortmund are now able to reveal the first detailed structure of a key protein complex for human cell division known as CCAN. By using cryo-electron microscopy, the researchers show important features of the complex’s 16 components and challenge previous assumptions about how the complex is able to recognize the centromere, a crucial region of chromosomes in cell division.
Leicester researchers are working with NHS partners in the East of England to lead the way in delivering the NHS’ goal of halving the amount of opioids prescribed for non-cancer pain by 2024.
Transistors, which are devices that control or amplify electrical signals and power, are one of the most ubiquitous components of modern electronics. The most widely used transistor is known as the MOSFET, which stands for metal–oxide–semiconductor field-effect transistor. MOSFETs have been in use since the 1960s and have typically relied on silicon to act as a semiconductor. The latest iteration of the MOSFET uses silicon carbide as a semiconductor, known as SiC MOSFET. This has many advantages, but it has not been widely adopted for medium-voltage power conversion. This is because of several challenges associated with SiC MOSFETs that researchers hope to solve by combining novel technologies.