New insights of how the HIV-1 assembles and incorporates the Env protein
Peer-Reviewed Publication
Assembly of HIV-1 takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, guided by Gag’s N-terminal matrix domain. Yet details of that virion assembly have been lacking for four decades. Researchers now provide the first atomic view of the matrix lattice, showing molecular details at 2.1 angstroms resolution, advancimg the understanding of key mechanisms of viral assembly and viral envelope protein incorporation.
Rensselaer Polytechnic Institute researchers have developed an accessible way to make N95 face masks not only effective barriers to germs, but on-contact germ killers. The antiviral, antibacterial masks can potentially be worn longer, causing less plastic waste as the masks do not need to be replaced as frequently.
A team led by the University of Washington has compiled and analyzed hundreds of these field observations to produce the first comprehensive report of the impacts of the 2021 heat wave on shellfish.
• Freiburg environmental meteorologists develop global techno-climatic scenarios and site projections until 2060 • Sufficient sites for efficient wind energy use are available worldwide • With optimal expansion and favorable climate development, efficiency can be increased globally by up to 23.5 percent by 2035
MIT engineers devised a recipe for improving any autonomous robotic system. Their optimization code can automatically identify how and where to tweak a system to improve a robot’s performance.
While access to food is a national concern, college students are experiencing food insecurity at a rate four times higher than the general public. A research article featured in the Journal of Nutrition Education and Behavior, published by Elsevier, discusses how students' use of a campus food pantry can positively affect their physical health, mental health and lead to improvements in sleep.
In this study published in the American Journal of Kidney Diseases (AJKD), over 60% of surveyed parents of children with kidney disease or hypertension reported they were unsure or unwilling to vaccinate their child against COVID-19. The high level of vaccination hesitancy among parents of children at high risk for COVID-19 demonstrates the urgent need for enhanced communication of vaccine information to parents.
A camera system developed by Carnegie Mellon University researchers can see sound vibrations with such precision and detail that it can reconstruct the music of a single instrument in a band or orchestra.Even the most high-powered and directed microphones can't eliminate nearby sounds, ambient noise and the effect of acoustics when they capture audio. The novel system developed in the School of Computer Science's Robotics Institute (RI) uses two cameras and a laser to sense high-speed, low-amplitude surface vibrations. These vibrations can be used to reconstruct sound, capturing isolated audio without inference or a microphone. "We've invented a new way to see sound," said Mark Sheinin, a post-doctoral research associate at the Illumination and Imaging Laboratory (ILIM) in the RI.
Although little is known about Professor Giorgi Eliava, without his avid support of bacteriophage research, our knowledge about phage therapy might not have been acquired. A tribute to the life of Professor Eliava and the institute he founded.
“Despite the prevalence and societal costs of pain in the United States, investment in pain medication development is low, due in part to poor understanding of the probability of successful development of such medications,” said the authors of a study published Online First in Anesthesiology, the official peer-reviewed journal of the American Society of Anesthesiologists (ASA). “The opioid crisis has highlighted the need for new therapeutics with low abuse potential to treat chronic pain,” they said. “While pharmaceutical companies recognize this need, because of the subjective nature of pain … the conduct of clinical trials for new drug approval is a lengthy and costly proposition.” According to the authors, a better understanding of the probability of the successful development of new pain medications would reduce some of the investment risks.
MIAMI, Fl.-- Recognizing the value of coral reefs in reducing erosion, flooding, and storm damage, the United States Defense Advanced Research Projects Agency (DARPA), has selected the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science as a top recipient of funding for its nationwide Reefense research program. Through this program, a team of University faculty will help address security threats to U.S. military and civilian infrastructure that lie along the coastline.
Today, U.S. Secretary of Energy Jennifer Granholm announced ten U.S. scientists and engineers as recipients of the prestigious Ernest Orlando Lawrence Award for their exceptional contributions in research and development supporting the Energy Department’s missions in science, energy, and national security. Established in 1959, the Lawrence Award recognizes mid-career U.S. scientists and engineers who have advanced new research and scientific discovery in nine categories representing the broad science and engineering missions of DOE and its programs. The awards are among the longest running and most prestigious science and technology awards bestowed by the U.S. Government.