Bottom Line: Concussion is a common brain injury. This observational study of nearly 29,000 adults (66 and older) diagnosed with concussion examined whether statin use was associated with risk of long-term dementia after a concussion. The analysis compared 7,058 patients who received a statin prescription in the 90 days after a concussion with 21,757 who didn't. After an average follow-up of four years, 4,727 patients developed dementia (1 in 6). The risk of dementia in older adults after concussion was substantial, and statin use was associated with modestly reduced risk compared to patients who didn't receive a statin. Limitations of the study include missing information on other factors that could influence the risk of dementia.
Authors: Donald A. Redelmeier, M.D., M.S.H.S.R., University of Toronto, and coauthors
(doi:10.1001/jamaneurol.2019.1148)
Editor's Note: The article includes funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
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JAMA Neurology