Leprosy remains one of the biggest public health problems in many countries. It is a complex disease in several aspects, including clinical, histopathological, and molecular. This book is written to help different professionals (medical students, physicians, pathologists, researchers, and others) who handle this disease daily or are interested in it to understand the disease from the perspective of pathology. The histopathological characteristics of leprosy throughout its spectrum, reaction phenomena, and clinical presentation types are crucial for understanding the pathophysiology of the disease and guiding clinical conduct and research accordingly.
The book 'Histopathological Diagnosis of Leprosy' is organized into eight sequential chapters that allow the readers to gradually immerse themselves in different histopathological aspects of leprosy. The clinical features discussed are accompanied by corresponding histopathological images presented as photo panels, along with key points that assist in understanding the described characteristics. Common histological sections stained by hematoxylin-eosin are complemented with those stained by Fite-Faraco to identify the different types of cells or tissues parasitized by Mycobacterium leprae. Immunohistochemical findings are used to clearly illustrate some characteristics observed in common histological sections. In some cases, more than one staining technique was used for the same histological section (for example, immunohistochemistry and Fite-Faraco), thereby contributing to a better understanding of the histopathological characteristics of the disease.
The interpretation of the histopathological characteristics of leprosy lesions is somewhat challenging. Each diagnosis depends on the close correlation between the findings of histopathology, bacilloscopy examination, and clinical data. In this context, histopathology is of great importance to confirm or dismiss a certain hypothesis and can guide teams to accurately interpret data and choose the best clinical and therapeutic conduct.
The detailed presentation of the book is of great value to both healthcare professionals (pathologists, dermatologists, physicians) who are involved in the care of leprosy patients, and medical residents who are seeking information about the disease as part of their medical training.
t value to both healthcare professionals (pathologists, dermatologists, physicians) who are involved in the care of leprosy patients, and medical residents who are seeking information about the disease as part of their medical training.About the Editor
Dr. Cleverson Teixeira Soares graduated in medicine from the University of Brasília (UnB) and completed his medical residency in Pathological Anatomy and doctorate in Gynecology, Obstetrics and Mastology from the Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP-Botucatu). He obtained specialization in Pathological Anatomy by the Brazilian Society of Pathology (SBP). Dr. Soares is currently the Chief Pathologist of the Pathology Service of the Lauro de Souza Lima Institute (ILSL), Bauru, São Paulo, with expertise in the field of anatomopathological diagnosis (surgical pathology, with an emphasis on dermatopathology and leprosy, fine needle aspiration cytology, immunohistochemistry, and molecular diagnosis). He is also a preceptor of the medical residency program in dermatology (ILSL) and medical internships in dermatopathology and leprosy. The research activities of Dr. Soares are in the field of pathological anatomy and leprosy.
Key words:
Leprosy, pathophysiology, bacilloscopy examination, Mycobacterium leprae, histopathology, Fite-Faraco, clinical data, hematoxylin-eosin
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