New strategy could prevent T cell exhaustion and boost immunotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Oct-2026 11:16 ET (28-Oct-2026 15:16 GMT/UTC)
Scientists have identified a new mechanism by which mitochondria, the powerhouses inside cells, communicate to cell nuclei to program changes in gene expression in neurons supporting brain development.
The team’s study, published in Science and led by researchers at Brown University and the Children’s Medical Center Research Institute at U.T. Southwestern, reveals that a deficiency in a particular metabolite in the nucleus is a key mechanism underlying the genetic disorder GPT2 deficiency.
A nationwide randomized clinical trial found that 28.4% of patients receiving 6 months of telehealth counseling and nicotine replacement therapy during cancer treatment were tobacco-free after 6 months, compared with 14.7% of patients referred to a Quitline without further support. The comprehensive approach, delivered through community oncology settings, achieved high participation (81% versus 5%), strong medication use (83% versus 49.5%), and high patient satisfaction (90% versus 40%). The results of this study by the ECOG-ACRIN Cancer Research Group demonstrate that integrating evidence-based, sustained tobacco treatment into routine cancer care is both feasible and highly effective.