Researchers at the University of Michigan Rogel Cancer Center identified a gene that plays a key role in prostate cancer cells that have transitioned to a more aggressive, treatment-resistant form. The gene can be indirectly targeted with an existing class of drugs, suggesting a potential treatment strategy for patients with aggressive subtypes of prostate cancer.

Patients with early-stage HER2+ breast cancer typically receive pre-operative multi-agent chemotherapy and anti-HER2 antibodies, followed by surgery and possibly more chemotherapy. The CompassHER2 pCR trial is evaluating a less intensive, reduced chemotherapy approach, the first large-scale study of its kind, but more follow-up is needed to assess its impact on survival. Meanwhile, researchers are reporting rates of pathologic complete response (pCR) at time of surgery, detailing which patients are most likely to benefit from the new approach.

E-cigarette warnings, especially those highlighting health harms, effectively discourage vaping without causing unintended consequences like increased cigarette smoking, according to a meta-analysis of 24 studies by University of North Carolina Lineberger Comprehensive Cancer Center researchers and their colleagues.

Georgia Tech researchers reveal the dynamic role of inhibitory neurons in spatial memory and learning.